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Tom O'Brien

CEO

Prior to founding Eclipse in 1993, Tom held several leadership positions throughout his career in the medical device industry. Having mastered both disposable and capital equipment sales for companies like C.R. Bard, Tom’s track record of success quickly established Eclipse as the go-to company to launch new technology in the surgical laser industry.

Over time Tom transitioned Eclipse from a leader in the OR surgical laser market to a key player in the aesthetic laser industry. Starting in 2011 Eclipse began a new mission of increasing adoption of Platelet-rich Plasma on a national level.

His vision and leadership has helped Eclipse become one of the most successful medical device companies in its space. Tom’s new mission is to bring game-changing Eclipse technologies in Platelet-Rich Plasma, Microneedling and Shockwave Therapy to the entire globe.

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Eclipse PRP®

The Eclipse PRP system utilizes a patented separator gel technology to isolate the platelets while eliminating the undesirable components such as red blood cells and inflammatory white blood cells. Many physicians now rely on Eclipse PRP injections as part of numerous treatments, from encouraging hair growth to promoting soft tissue-healing.

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Easy Spin 3-Step Process

Step 1: Collect Patients Blood (11ml or 22ml tube) and Centrifuge (10 min.)

Step 2: Extract Platelet Poor Plasma (PPP)

Step 3: Collect Platelet Rich Plasma (PRP) and apply

See how the Easy Spin Centrifuge can deliver the most comprehensive treatment, in less time.

What is Platelet-Rich Plasma?

Platelet-Rich Plasma (PRP) is an autologous concentrated preparation of platelets and the associated growth factors in a small volume of plasma. Platelets are a natural source of numerous growth factors available in their natural and biologically-determined ratios. The concentration of platelets — and, thereby, the concentration of growth factors in PRP — can be 5 to 10 times greater (or richer) than whole blood.

Learn more about how Eclipse PRP can be used in your practice.

What do Platelets do?

Platelets release growth factors which regulate the healing cascade by signaling to surrounding cells to repair damaged tissue and regenerate new tissue. Key growth factors involved in this process include but are not limited to:

  • Platelet-Derived Growth Factor (PDGF)
  • Transforming Growth Factor group (TGF)
  • Epidermal Growth Factor (EGF)
  • Vascular Endothelial Growth Factor (VEGF)
  • Fibroblast Growth Factor (FGF)
  • Keratinocyte Growth Factor (KGF)

Learn More about PRP

What’s in the syringe matters!



• Platelet concentration in supraphysologic range


• Removes the most contaminating red blood cells


• Removes the most inflammatory white blood cells

Platelets – Supraphysiologic Range is Optimal


Animal in vitro Clinical Studies Support 1.5 – 3 X Baseline

Those methods with lower concentrations of platelets – 1 to 3 times baseline – showed more robust healing rates than those with higher concentrations 3 to 8 times baseline.1

The use of highly concentrated platelet preparations appeared to have an inhibitory influence…reasons could be unwanted inhibitory and cytotoxic effects of growth factors at such high concentrations.2

PRP might exert positive effects…in a dose-dependent manner up to a certain level, but adverse effects occur when it is highly concentrated.3

Optimal results were observed at a platelet concentration of 2.5 X...increased concentrations resulted in a reduction in proliferation and a suboptimal effect on osteoblast function.4

These data reject the hypothesis that increases the concentration of platelets in PRP is beneficial for articular cartilage and the meniscus; furthermore, these findings suggest that high platelet concentrations for intra-articular injection should be considered with caution.5

Features

Vacuum Filled, Internally Coated Glass Tube designed to: • Prevent platelets from “sticking” to tube walls.
• Precisely draw blood at a pressure that prevents lysing of the cells

Proprietary Anti-Coagulant (MNC7) modified to • Reduce acidity while preventing coagulation of platelets.
• Deliver non-activated platelets physically positioned on top of gel

Patented Separator Gel designed to • Spare the 90% of platelets above
• Remove 99.9% of RBC below
• Remove 92% of granulocytes

Example Shown: 22mL Tube

5 Reasons to Avoid Red & White Blood Cells in PRP


RED BLOOD CELLS
  1. Lead to free radical formation6,7
  2. Inflammation6,7
  3. Vascular injury6,7
  4. Cell death (apoptosis)6,7
  5. May lead to Hemosiderin staining from iron oxide (rust). This is a permanent bruise.

WHITE BLOOD CELLS
  1. Release matrix metalloproteinases and produce oxygen radicals8
  2. Tissue damage8
  3. Inflammation9
  4. Impaired healing9
  5. Local pain10
There is no biologic rationale to include RBC or WBC in PRP preparations and their presence is based on the inability of other processing technologies to completely eliminate these cells from the PRP.

Cell Count & Growth Factor Statistics

Eclipse PRP
Platelet concentration fold*
1.8x
RBC (106/ul)
0.0
WBC (103/ul)
0.2
Granulocytes %
8.5
Mononuclear cells %
86.2
PDGF (pg/ml)
2048
VEGF (pg/ml)
220
EGF (pg/ml)
269

*An average of several independent, validated tests using the collection method outlined in this guide for the 11mL Eclipse PRP tube without the removal of PPP.
Eclipse PRP HC
Platelet concentration fold*
3.2x
RBC (106/ul)
0.0
WBC (103/ul)
0.2
Granulocytes %
8.5
Mononuclear cells %
86.2
PDGF (pg/ml)
2048
VEGF (pg/ml)
220
EGF (pg/ml)
269

*STD DEV. Mean concentration using 22ml tube, removing 6-7ml of platelet poor plasma (PPP) in patients with whole blood platelet counts ranging from 169,000 to 356,000 per microliter.


References
1. Rappl LM et al., Int Wound J 2011; 8:187-195.
2. Weibrich G et al., Bone 2004; 34:665-671.
3. Yamaguchi R et al., J Surg Res 2012; 173(2): 258-266.
4. Graziani F et al., Clin Oral Impl Res 2006; 17: 212-219.
5. Kisiday et al, Cartilage 2012; 3(3): 245-254.
6. Belcher et al., Antioxidants & Redox Signaling 2010; 12(2): 233-48.
7. Kumar et al., Toxicol lett 2005; 157 (3): 175-188.
8. Tidball, Am J Physiol Regul Integr Comp Physiol 2005; 288: R345-353.
9. Muylle, Transfusion 1993; 33(3): 195-199.
10. Mei-Dan, Br J Sports Med 2010; 44: 618-619.

Eclipse Difference

Simple: Fewer steps than other PRP (platelet-rich plasma) kits
Excellence: Optimal platelet recovery 87% ± 10%
Fast: Centrifuge with a single spin in a matter of minutes
Patient Friendly: Small volume of blood required
Excellent Value: High volume PRP yield, low cost per mL
~6 mL PRP per 11 mL tube
~12 mL PRP per 22 mL tube
Consistent Platelet Concentration: Allowing for predictable performance

Learn more about Eclipse PRP

Regulatory Status

FDA cleared 510(k) Class II medical device. Eclipse PRP is intended for the safe and rapid preparation of autologous platelet-rich plasma (PRP) from a small sample of blood at the patient point of care. The PRP is mixed with autograft or allograft bone prior to application to a bony defect for improving handling characteristics. 510(k) number: BK110035

Combination Therapies with PRP

Learn how using PRP as part of a combination treatment can make a significant impact on your patients’ outcomes.

  • PRP and Microneedling
  • PRP and Hair Restoration
  • PRP and Sexual Wellness
  • PRP and Soft-Tissue Repair